Biodegradable click capsules with engineered drug-loaded multilayers

CJ Ochs; GK Such; Y Yan; MP Van Koeverden; F Caruso

Journal article

Biodegradable click capsules with engineered drug-loaded multilayers

CJ Ochs, GK Such, Y Yan, MP Van Koeverden, F Caruso

ACS Nano | AMER CHEMICAL SOC | Published : 2010

DOI: 10.1021/nn9014278

Abstract

We report the modular assembly of a polymer-drug conjugate into covalently stabilized, responsive, biodegradable, and drug-loaded capsules with control over drug dose and position in the multilayer film. The cancer therapeutic, doxorubicin hydrochloride (DOX), was conjugated to alkyne-functionalized poly(Lglutamic acid) (PGAAlk) via amide bond formation. PGA Alk and PGAAlk+DOX were assembled via hydrogen bonding with poly(N-vinyl pyrrolidone) (PVPON) on planar and colloidal silica templates. The films were subsequently covalently stabilized using diazide cross-linkers, and PVPON was released from the multilayers by altering the solution pH to disrupt hydrogen bonding. After removal of the sa..

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University of Melbourne Researchers

Georgina Such Author

Martin van Koeverden Author

Frank Caruso Author

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Funding Acknowledgements

The authors thank C. R. Kinnane for the ellipsometry measurements. This work was supported by the Australian Research Council under the Federation Fellowship (F.C.) and Discovery Project (G.KS.; F.C.) schemes.